R Flora, M Zulkarnain, N A Fajar, A F Faisya, Nurlaily, Ikhsan, S Slamet


Children living in malaria-endemic regions are at risk of developing anemia particularly iron deficiency anemia (IDA). Iron is a very essential mineral needed by the body to help make hemoglobin, process cell division, stimulate brain cell growth, build muscle cells, and strengthen the immune system. Iron deficiency in primary school children has a significant impact on their immune system, cognitive skills, and learning achievement. The objective of this study was to analyze serum iron levels of primary school children in malaria-endemic regions in Seluma Regency, Bengkulu Province. The research design was a cross-sectional study. The research population was primary school children aged 9-11 years old in Seluma Regency Bengkulu Province collected from five subdistricts. The sample size was seventy-nine children collected by using a simple random sampling technique. The research data of this study were obtained from questionnaires (data for characteristics of parents and children), blood tests (data for hemoglobin, TIBC, saturated transferrin, and malaria), and fecal examinations (data for helminthiasis). The data were then analyzed in univariate and bivariate using SPSS. The hematology tests showed that the mean level of hemoglobin was 13.41 ± 2.21 g/dL, serum iron was 43.42 ± 19.88 μg/dL, TIBC was 301.65 ± 65.02 μg/dL, and saturated transferrin was 15.185 ± 8.15%. Based on these laboratory findings, 15.18% of the children were suffering from iron-deficiency anemia, 12.65% were anemia, 49.39% were iron deficiency, and 22.78% were in a normal range. The minimum level of serum iron was found in children with iron deficiency (34.19 ± 10.46 μg/dL). The results of statistical analysis using ANOVA indicated that there was a significant difference (p < 0.05) in the mean level of serum iron among children with iron deficiency anemia, iron deficiency, anemia, and normal range. The blood smears for malaria parasites showed that all children (100%) were not infected with helminthiasis. On the other hand, from the fecal examination, it was shown that twenty-six children (32.9%) were positive with helminthiasis. There was no significant correlation (p > 0.05) between hemoglobin level and helminthiasis. Almost half of the primary school children living in malaria-endemic regions of Seluma Regency, Bengkulu Province are suffering from iron deficiency. Infection of malaria parasites and helminthiasis do not contribute to iron deficiency in primary school children living in malaria-endemic regions of Seluma Regency, Bengkulu Province.

Keywords: iron serum, iron deficiency, iron deficiency anemia, primary school children, malaria-endemic areas

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Breman JG, 2001. The ears of the hippopotamus: manifestations, determinants and estimates of the malaria burden. Am J Trop Med Hyg 64(suppl 1): 1–11.

WHO. The Global Malaria Action Plan. Geneva: WHO; 2008

Menendez C, Fleming AF, Alonso PL, 2000. Malaria-relatedanaemia. Parasitol Today 16:469– 476.

Ekvall H, 2003. Malaria and anemia.Curr Opin Hematol 10:108–114

Glinz D, Hurrell RF, Righetti AA, Zeder C, Adiossan LG,Tjalsma H, et al. In Ivorian school-age children, infectionwith hookworm does not reduce dietary iron absorptionor systemic iron

utilization, whereas afebrile Plasmodiumfalciparum infection reduces iron absorption by half.American Journal of Clinical Nutrition2015;101(3):462–70.

Beard JL. Iron biology in immune function, musclemetabolism and neurological functioning.The Journal of Nutrition2001;131(2):568S–80S

World Health Organization. Iron deficiency anaemia assessment, prevention, and control. A guide for programme managers. Geneva (Switzerland): World Health Organization; 2001.

Riset Kesehatan Dasar(Riskesdas). (2013).Badan Penelitian dan Pengembangan Kesehatan

Kementerian RI tahun 2013.Diakses: 19 Oktober 2014, dari

Peraturan Presiden Nomor 131 Tahun 2015 tentang Penetapan Daerah Tertinggal Tahun 2015-2019

Gitonga CW, Edwards T, Karanja PN, Noor AM, Snow RW, Brooker SJ. Plasmodium infection, anaemia and mosquito net use among school children across diferent settings in Kenya. Trop Med Int Health. 2012;17:858–70.

[Osazuwa F, Ehigie F (2010) Prevalence of anemia in preschool and school aged children in Nigeria. J of New York Science 2(20): 212–213.

Menendez C, Fleming AF, Alonso PL (2000) Malaria related anaemia. Parasitol Today 16: 469–476.

McDevitt MA, Xie J, Gordeuk V, Bucala R (2004) The anemia of malaria infection: The role of inflammatory cytokines. Curr Hematol Rep 3: 97–106

Carrilho G F, DaCosta G M, Olivi M J, et al. 2011 Anemia in patients with intestinal parasitic infections Parasitol. 70(6) 206-11

Adebara O V, Ernest S K and Ojuawo I A 2011 Association between intestinal helminthiasis and serum ferritin levels among school children Scientific Res.: Open J. Pediatr. (1) 12-6

Beard JL, Dawnson H, Pinero DJ. Iron metabolism: a comprehesive review. Nutr Rev 1996;54:295-317.

Lozoff B, Kaciroti N, Walter T. Iron deficiency in infancy: applying a physiologic framework for prediction. Am J Clin Nutr 2006;84(6):1412-1421. 75.

Lozoff B, Smith JB, Kaciroti N, Clark KM, Guevara S, Jimenez E. Functional significance of early-life iron deficiency: outcomes at 25 years. J Pediatr 2013;163(5):1260-1266.

Georgieff MK. Long-term brain and behavioral consequences of early iron deficiency. Nutr Rev 2011;69 Suppl 1:S43-S48.

Oppenheimer SJ. Iron and its relation to immunity and infectious disease. J Nutr 2001;131(2S-2):616S633S

Lozoff B, Jimenez E, Wolf AW. Long-term developmental outcome of infants with iron deficiency. N Engl J Med 1991;325(10):687-694.

Lozoff B, Jimenez E, Hagen J, Mollen E, Wolf AW. Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics 2000;105(4):E51

Lee R, Herbert V (1999) Clinical hematology: Nutritional factors in the production and function of erythrocytes. 10th edition. Williams and Wilkins; 228–266.

Osazuwa Favour. A Significant Association Between Intestinal Helminth Infection and Anaemia Burden in Children in Rural Communities of Edo state, Nigeria. North American Journal of Medical Sciences 2011: 3(1).

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