Akbar Satria Fitriawan, Ririn Wahyu Widayati, Wiwit Ananda W.S, , Nur Arfian, Dwi Cahyani Ratna Sari


Diabetes mellitus is one of the major health problems and tends to increase throughout the years. Uncontrolled diabetes mellitus causes both microvascular and macrovascular complication. One of the active compounds of Centella asiatica (CeA) extract is madecassic acid which acts as an agonist of PPAR-. Through PPAR- activation, CeA enhances the expression of the lipolysis regulator proteins such as perilipin and Angptl-4, reduces NEFA production, prevents meta-inflammation, and increases insulin sensitivity. But no study has been conducted to evaluate the effect of long-term administration of CeA extract on chronic diabetes mellitus. We aim to elucidate the effect of longterm of CeA extract administration on blood glucose levels and lipid profiles in diabetic rats. Diabetes mellitus induced through single dose injection of Streptozotocin 60 mg/kgBW intraperitoneally for 1 month (DM1M) and two months (DM2M). Centella asiatica (CeA)-treated groups (400 mg/KgBW/day) were administered per-orally for 1 month (DM1C) and 2 months (DM2C) to diabetes mellitus rats. After the due date, the rats were sacrificed and the blood was taken from retro-orbital vein to assess blood glucose, cholesterol, triglyceride, and LDL levels. CeAtreated groups significantly diminished blood glucose and cholesterol levels compared to diabetes mellitus groups (p<0.05). Two months but not a month CeA-treated groups showed significantly decreased of LDL level (p<0.05) compared to diabetes mellitus groups. Moreover, the triglyceride level significantly increased (p<0.05) in CeA-treated groups compared to diabetes mellitus groups. Centella asiatica extract exerts antidiabetic and hypolipidemic activity on chronic streptozotocininduced diabetic rats.

Keywords: antidiabetic, hypolipidemic, Centella asiatica, diabetes mellitus

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